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Welcome to our Sioux Falls Southwest Hotel!Welcome to Sioux Falls, the largest city in South Dakota. With Sioux Falls being the retail and medical hub in our state, our hotel is located right where you want to be! With easy Interstate access off of I-29 and I-229, our hotel is not only easy to find but is minutes from the Empire Mall for your shopping experience. Corporate guests looking for hotels in Sioux Falls, SD need look no further than this Holiday Inn Express &Suites hotel which offers a state of the art business center, free fast high speed Internet, an expanded fitness facility with Precor equipment, and 900 square feet of meeting space. We are just a short drive from businesses like the Avera Heart Hospital and Corporate offices, Good Samaritan, Vance Thompson, Missouri River Energy Services, and Ophthalmology Limited. Families can enjoy a stress free trip when they stay with us in Sioux Falls, SD. At our hotel, we pride ourselves in providing you with a great location closest to the most popular attractions, including the Sertoma Butterfly House and Wild Water West Amusement Park, and Yankton Trails.